課程資訊
課程名稱
臨床影像學二
Fundamentals of Medical Imaging(Ⅱ) 
開課學期
108-1 
授課對象
醫學院  物治系六年制  
授課教師
湯佩芳 
課號
PT4038 
課程識別碼
408 43340 
班次
 
學分
1.0 
全/半年
半年 
必/選修
必帶 
上課時間
星期三8(15:30~16:20) 
上課地點
公衛212 
備註
與邱銘章、鄭建興、彭信逢、周弘傑、陳雅芳、賴達明、湯頌君、曾文毅合授
限學士班四年級 且 限本系所學生(含輔系、雙修生)
總人數上限:40人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/1081PT4038_ 
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課程概述

本課程為物理治療學系六年學制學生之必修課程,課程內容為成人與小兒常見神經內外科疾病之神經、血管臨床影像判讀,以養成物理治療核心專業能力。內容主要涵蓋﹕(一)神經發展與神經解剖學概觀;(二)電腦斷層(含電腦斷層灌流)造影、磁振造影、血管攝影、正子攝影、與神經超音波等影像成像原理之介紹;(三)正常與異常影像判讀原則;(四)主要成人與小兒神經內外科疾病(含腦中風、頭部外傷、水腦、腦腫瘤、巴金森氏症、失智症、脊髓損傷、脊髓腫瘤與病變、腦性麻痺、遺傳性腦疾病、腦先天畸形等)之神經、血管臨床影像判讀。本課程採多元學習方式進行,除授課教師講授相關知識之外,亦包含問題導向學習(PBL)、課堂討論與報告等學習活動,以培養學生專業能力、批判思考、終身學習、和跨領域溝通以及團隊合作能力。 

課程目標
修習學生在結束本課程後,應能:
1. 瞭解電腦斷層、磁振造影、血管攝影、正子攝影、與神經超音波等之影像原理;
2. 瞭解如何判讀正常之電腦斷層腦與磁振造影腦部與脊髓影像;
3. 瞭解如何判讀血管攝影與神經超音波影像;
4. 瞭解如何判讀主要成人即小兒神經內外科疾病之神經、血管影像;
5. 瞭解神經、血管影像判讀結果與臨床表徵間的關係;
6. 學習應用神經、血管影像資訊於成人神經物理治療及小兒神經物理治療主要臨床疾病類別之臨床決策。
 
課程要求
先修科目: 機能解剖學 
預期每週課後學習時數
 
Office Hours
另約時間 
指定閱讀
 
參考書目
I. Neuroanatomy textbooks
A. Haines DE. Neuroanatomy: An Atlas of Structures, Sections, and
Systems. 9th Ed. Philadelphia: Wolters Kluwer. 2015.
B. Kiernan JA, Rajakumar N. Barr’s The Human Nervous System: An
anatomical Viewpoint. 10th Ed. Philadelphia: Wolters Kluwer Lippincott
Williams & Wilkins, 2014.
C. Mai JK and Paxinos G. The human nervous system [electronic
resource]. 3rd Ed. Burlington: Elsevier Science, 2011
D. Mai JK, Paxinos G, Voss T. Atlas of the human brain. 3rd Ed. New
York: Academic Press. 2008.
E. Vanderah, TW. Nolte’s the Human Brain: An Introduction to Its
Functional Anatomy [electronic resource]. 7th ed. Philadelphia, PA:
Elsevier. 2016.

II. Neuroscience textbooks
A. Bear M, Connors B, Paradiso M. Neuroscience: Exploring the brain, 3
ed. Baltimore: Lippincott Williams & Wilkins. 2016.
B. Purves D, Augustine GJ, Fitzpatrick D, Hall WC, LaMantia A-W, White
LE. Editors. Neuroscience. 5th Ed. Sunderland, MA, USA: Sinaur Associates,
Inc. 2012.
C. Lundy-Ekman L. Neuroscience Fundamentals for Rehabilitation. 4rd ed.
St. Louis: Saunders Elsevier; 2013

III.  Neuroimaging textbooks
A. Cho ZH (Editor). 7.0 Tesla MRI Brain Atlas (2nd Ed.) [electronic
resource]. Berlin, Heidelberg: Springer. 2015.
B. Gillard JH, Waldman AD, and Barker PB. Clinical MR Neuroimaging:
Physiological and Functional Techniques (2nd ed). New York: Cambridge
University Press. 2010.
C. Naidich TP. Duvernoy's Atlas of the Human Brain Stem and Cerebellum
[electronic resource]: High-field MRI: Surface Anatomy, Internal Structure,
Vascularization and 3D Sectional Anatomy. Vienna: Springer Vienna. 2009.
D. Sanelli PC et al. Neuroimaging: the Essentials. Philadelphia:
Wolters Kluwer. 2016.
E. Scarobino T, Pollice S, Popolizio T (Editors). High Field Brain MRI:
Use in Clinical Practice (2nd Ed.) [electronic resource]. Cham: Springer
International Publishing. 2017.
F. Scott W. Atlas (Editor). Magnetic Resonance Imaging of the Brain and
Spine [electronic resource]. 5th ed. Philadelphia: Lippincott Williams &
Wilkins, 2017.
G. Scott W. Atlas (Editor) MRI of the brain and spine [electronic
resource]. Philadelphia: Lippincott Williams & Wilkins. 2008.
H. Talairach, J. Co-planar Stereotaxic Atlas of the Human Brain : 3-
dimensional Proportional System: An Approach to Medical Cerebral Imaging.
NY: Thieme Medical Publishers.
I. Westbrook C, Roth CK, TalbotJ. MRI in Practice (4th ed). Chichester,
West Sussex ; Malden, MA : Wiley-Blackwell. 2011.
J. Westbrook C. MRI at a Glance (2nd ed). Chichester, U.K. ; Malden, MA
: Wiley-Blackwell. 2010.
K. 陳煥武編譯(Catherine Westbrook原著)。圖解核磁共振造影學。台北市:合記。
2006。

IV. Other readings: to be determined by instructors
A. Basic principles of imaging
1. Goldman LW. Principles of CT and CT technology. J Nucl Med Technol
2007;35:115-128; quiz 129-130.
2. Currie S, Hoggard N, Craven IJ, Hadjivassiliou M, Wilkinson ID.
Understanding MRI: basic MR physics for physicians. Postgrad Med J
2013;89:209-223.
3. Townsend DW. Physical principles and technology of clinical PET
imaging. Ann Acad Med Singapore 2004;33:133-145.
B. Aging brain
1. Jagust W, D’Esposito M. Imaging the Aging Brain [electronic
resource]. Oxford Scholarship Online. 2009.
C. Stroke
1. Bivard A, Spratt N, Miteff F, Levi C, Parsons MW. Tissue Is More
Important than Time in Stroke Patients Being Assessed for Thrombolysis.
Frontiers in neurology 2018;9:41.
2. Campbell BC, Parsons MW. Imaging selection for acute stroke
intervention. Int J Stroke 2018;13:554-567.
3. Tsivgoulis G, Katsanos AH, Schellinger PD, et al. Advanced
Neuroimaging in Stroke Patient Selection for Mechanical Thrombectomy. Stroke
2018;49:3067-3070.
4. Vilela P, Rowley HA. Brain ischemia: CT and MRI techniques in acute
ischemic stroke. Eur J Radiol 2017;96:162-172.

V. Other electronic resources
A. de Asis Bravo-Rodriguez F, Diaz-Aguilera R. Hygino Cruz Jr. LC.
(Editors) Learning Neuroimaging [electronic resource]: 100 essential cases.
Berlin, Heidelberg: Springer-Verlag Berlin Heidelberg. 2012.
B. Espinosa PS, Smith CD. Neurology Self-Assessment: Focus on
Neuroimaging [electronic resource]. Philadelphia: Lippincott Williams &
Wilkins. 2009. (叢書名Neurology self-assessment)
C. Barkovich AJ, Raybaud C. Pediatric Neuroimaging [electronic
resource]. Philadelphia: Wolters Kluwer Health/Lippincott Williams &
Wilkins. 2012.
D. Barkhof F. et al. Neuroimaging in Dementia [electronic resource].
Berlin, Heidelberg : Springer-Verlag Berlin Heidelberg. 2011.
E. https://3d4medical.com/apps/radiology-head

 
評量方式
(僅供參考)
 
No.
項目
百分比
說明
1. 
上課參與、討論、及報告 
20% 
 
2. 
期中考 
40% 
 
3. 
期末考 
40% 
 
 
課程進度
週次
日期
單元主題
第1週
9/11  Course overview
Review of neural development, and brain and spinal cord anatomy
 
第2週
9/18  Brain anatomy review: using brain slices and on-line images (PBL) 
第3週
9/25  Introduction to medical imaging: CT (non-contrast, contrast, perfusion, angiography), MRI (basic structure, diffusion, susceptibility, angiography, perfusion, and spectroscopy), and PET (PET CT) 
第4週
10/02  Applications of CT and MRI images
Neuroimaging of the normal adult brain and spine: Guides for reading normal images
 
第5週
10/09  CT and MRI images of neurological disorders (I): cerebrovascular disease and white matter lesions 
第6週
10/16  CT and MRI images of neurological disorders (II): brain tumors, infection, multiple system atrophy, spinal disorders  
第7週
10/23  Midterm reports by group 
第8週
10/30  Pediatric neuroimaging  
第9週
11/06  Neonatal brain ultrasonic imaging  
第10週
11/13  Ultrasonic imaging in adult neurological disorders  
第11週
11/20  Presentations of stroke neuroimaging readings by group 
第12週
11/27  Neuroimaging in acute ischemic stroke 
第13週
12/04  Neuroimaging in normal aging brain and in Parkinson’s disease and other basal ganglia disorders 
第14週
12/11  Neuroimaging in dementia 
第15週
12/18  Neuroimaging in cerebral hemorrhage, hydrocephalus, traumatic brain injury, and brain tumors before and after surgical procedures 
第16週
12/25  Neuroimaging in spinal disorders before and after surgical procedures 
第17週
1/01  開國紀念日(放假日) 
第18週
1/08  Final examination